Catalog Number - 68508-15P

Cogent RP C8™ HPLC Columns are designed for reliable reversed-phase chromatography using a traditional octyl (C8) bonded stationary phase. Manufactured with ultra-high purity silica and fully double end capped bonding technology, these columns provide reproducible retention, excellent peak shape, and long column life. The RP C8™ phase is a USP L7 equivalent chemistry and is commonly used as an alternative for methods developed on similar C8 phases. Compared to C18 columns, RP C8™ generally provides lower hydrophobic retention while maintaining excellent selectivity for many neutral and non-polar compounds.

68508-15P is packed with 5 µm RP C8™ particles featuring a 100 Å pore size in a 4.6 mm ID x 150 mm length format. The 150 mm column length provides increased resolving power and greater peak capacity than shorter analytical columns, making it ideal for complex sample separations and demanding analytical methods. The RP C8™ stationary phase is particularly useful for hydrophobic compounds, neutral analytes, and long-chain fatty acids where somewhat lower retention than a comparable C18 column is preferred. The 5 µm particle size provides low backpressure and dependable performance on conventional HPLC systems.

This column size is one of the most popular starting points for new method development and is frequently selected as a replacement for methods specifying USP L7 chemistry. The combination of 150 mm length and 4.6 mm internal diameter offers an excellent balance of resolution, robustness, and compatibility with standard analytical HPLC instrumentation. Typical flow rates of approximately 1.0-2.0 mL/min provide optimal performance for most analytical applications.

Key Benefits

• RP C8™ stationary phase

• USP L7 equivalent chemistry

• Octyl (C8) bonded phase

• Fully double end capped

• Ultra-high purity silica support

• 100 Å pore size

• High resolving power

• Lower retention than C18 phases

• Low backpressure with 5 µm particles

• Excellent starting point for method development

Typical Applications

• Reversed-phase HPLC

• USP L7 method substitution

• Method development

• Pharmaceutical analysis

• Long-chain fatty acid analysis

• Hydrophobic compound separations

• Neutral compound analysis

• Environmental testing

• Food and beverage analysis

• Quality control testing

Specifications

• Product Type: HPLC Column

• Stationary Phase: RP C8™

• USP Classification: L7

• Chromatography Mode: Reversed Phase

• Bonded Phase: Octyl (C8)

• Endcapping: Fully Double End Capped

• Particle Size: 5 µm

• Pore Size: 100 Å

• Column Dimensions: 4.6 mm ID x 150 mm

• Recommended Flow Rate: 1.0-2.0 mL/min

• Column Hardware: Stainless Steel

• Brand: Cogent

Important Notes

• Designed for high-resolution reversed-phase HPLC separations

• Provides lower retention than comparable C18 columns

• Suitable for hydrophobic and moderately non-polar compounds

• Excellent choice for long-chain fatty acid separations

• Frequently selected for USP L7 method replacement and transfer

• 150 mm length provides greater resolving power and peak capacity

• 5 µm particles provide low backpressure and broad instrument compatibility

• Compatible with standard HPLC systems operating at conventional analytical flow rates

• Commonly used as a starting column for new analytical method development

• Manufactured using ultra-high purity silica and fully double end capped bonding technology